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■ A Facile One-Pot Synthesis of Benzimidazoles from 2-Nitroanilines by Reductive Cyclization

Zheng Liu, Haihong Li, Qingjie Zhao, and Jingshan Shen

*Shanghai Institute of Materia Medica, The Chinese Academy of Sciences, 319 Yue-Yang Raod, Shanghai 200031, China

Abstract

A facile one-pot process to prepare benzimidazole derivatives is described. Reductive cyclization of a serial of 2-nitroanilines with orthoesters in the presence of Pd/C in methanol at room temperature, which is promoted by a catalytic amount of acetic acid, affords the corresponding benzimidazole derivatives in high yields.