Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 75, No. 9, 2008, pp.2301-2307
Published online, 28th April, 2008
DOI: 10.3987/COM-08-11399
Synthesis of 1,4-Dihydro-2H-3,1-benzoxazin-2-ones by Hydriodic Acid Mediated Cyclization of tert-Butyl 2-Vinylphenylcarbamates

Kazuhiro Kobayashi,* Shuhei Fukamachi, and Hisatoshi Konishi

*Department of Materials Science, Faculty of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan

Abstract

A two-step facile synthesis of 4,4-disubstituted 1,4-dihydro-2H-3,1- benzoxazin-2-ones starting from ±-substituted 2-aminostyrenes is described. The method involves the hydriodic acid mediated cyclization of t-butyl 2-vinylphenylcarbamate derivatives, which could be easily prepared by N-t-butoxycarbonylation of ±-substituted 2-aminostyrene derivatives, under mild conditions.