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Note | Regular issue | Vol 75, No. 10, 2008, pp.2535-2540
Published online, 29th May, 2008
DOI: 10.3987/COM-08-11416
Kopreasin A, a New Indole Alkaloid from Kopsia arborea

Kazumasa Zaima, Yosuke Matsuno, Yusuke Hirasawa, Abdul Rahman, Gunawan Indrayanto, Noor Cholies Zaini, and Hiroshi Morita*

*Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

A new alkaloid, kopreasin A (1) was isolated from the leaves of Kopsia arborea (Apocynaceae) together with ten known indole alkaloids (2 - 11), and the structure was elucidated by NMR spectral analysis using 2D techniques. These indole alkaloids showed a moderate vasorelaxant activity on isolated rat aorta ring.