Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 75, No. 11, 2008, pp.2703-2711
Published online, 23rd June, 2008
DOI: 10.3987/COM-08-11434
A Facile Synthesis of 2-Difluoromethyl-6-methylpyridine-3,5-dicarboxylates

Isamu Katsuyama,* Kazumasa Funabiki, Masaki Matsui, Hiroshige Muramatsu, and Katsuyoshi Shibata

*OAP 25F, Hitec Co., Ltd., 1-8-30 Temmabashi, Kita-ku, Osaka-shi, Osaka 530-6025, Japan

Abstract

α,β-Unsaturated trifluoromethyl ketones 1 react with primary enamines 2 in the presence of phosphorus oxychloride / pyridine adsorbed on silica gel, providing 1,4-dihydro-2-methyl-6-trifluoromethylpyridines 3, which undergo dehydrofluorination by use of DBU/piperazine, giving moderate to high yields of 2-difluoromethyl-6-methylpyridine-3,5-dicarboxylates 4.