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Note | Regular issue | Vol 75, No. 11, 2008, pp.2825-2833
Published online, 7th July, 2008
DOI: 10.3987/COM-08-11453
A Convenient One-Pot Three Component Approach to Synthesis of Highly Substituted Iminothiazolines

Heshmat Allah Samimi, Manouchehr Mamaghani,* and Khalil Tabatabaeian

*Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran

Abstract

An efficient one-pot three component method was developed for the synthesis of highly substituted 2-iminothizolines by the reaction of isothiocyanates, primary amines and α-bromoketones in ambient temperature. The reaction produced the desired products in a completely regioselective manner in excellent yields (78-94%).