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Paper | Special issue | Vol 76, No. 1, 2008, pp.401-428
Published online, 4th April, 2008
DOI: 10.3987/COM-08-S(N)21
Synthesis of 1,2,4-Trisubstituted Imidazoles and 1,3,5-Trisubstituted 1,2,4-Triazoles

Corinne Baumgartner, Lukas Brändli, and François Diederich*

*Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, HCI, CH-8093 Zürich, Switzerland


We report synthetic strategies to easily access 1,2,4-trisubstituted imidazoles by introduction of different residues at C(2) and C(4) followed by substitution at N(1). Furthermore, a synthesis of trisubstituted 1,2,4-triazoles via a cyclization of hydrazonamides is described.