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Paper | Special issue | Vol 76, No. 1, 2008, pp.455-469
Published online, 8th April, 2008
DOI: 10.3987/COM-08-S(N)30
Synthetic Studies on Mycobacterium tuberculosis Specific Fluorescent Park’s Nucleotide Probe

Kai Li and Michio Kurosu*

*Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523-1682, USA.

Abstract

An efficient synthesis of N-glycolyl Park’s nucleotide, a Mycobacterium tuberculosis (Mtb) specific peptidoglycan precursor, analog-fluorescein conjugate, is achieved. A fluorescent conjugated Mtb Park’s nucleotide analog 5 would be a very useful probe for the characterization of Mtb MraY, catalyzing the biosynthesis of lipid I from UDP-N-acyl-Mur-pentapeptide, and for the development of high-throughput screening (HTS) for Mtb MraY inhibitors.