Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 76, No. 2, 2008, pp.1001-1005
Published online, 29th May, 2008
DOI: 10.3987/COM-08-S(N)62
Synthesis of γ-Valerolactones as the Tea Catechin Metabolites

Sousuke Nakano, Masahiro Hamada, Takao Kishimoto, and Noriyuki Nakajima*

*Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan

Abstract

The synthesis of optically active γ-valerolactones in order to characterize the absolute configuration of the one of the (-)-epicatechin gallate metabolites was described. The determination of stereochemistry at C(4) position of γ-valerolactone suggested that C(3) position of tea catechins was converted to the C(4) position of γ-valerolactone by maetabolism.