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Communication | Special issue | Vol 76, No. 2, 2008, pp.1001-1005
Published online, 29th May, 2008
DOI: 10.3987/COM-08-S(N)62
Synthesis of γ-Valerolactones as the Tea Catechin Metabolites

Sousuke Nakano, Masahiro Hamada, Takao Kishimoto, and Noriyuki Nakajima*

*Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan


The synthesis of optically active γ-valerolactones in order to characterize the absolute configuration of the one of the (-)-epicatechin gallate metabolites was described. The determination of stereochemistry at C(4) position of γ-valerolactone suggested that C(3) position of tea catechins was converted to the C(4) position of γ-valerolactone by maetabolism.