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Communication | Special issue | Vol 76, No. 1, 2008, pp.243-247
Published online, 28th April, 2008
DOI: 10.3987/COM-08-S(N)72
Enantiomeric Synthesis of 2-C-Methyl-D-erythritol 2,4-Cyclodiphosphate

Prabagaran Narayanasamy* and Dean C. Crick*

*Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523-1682, USA

Abstract

Enantiomerically pure 2-C-methyl-D-erythritol 2,4-cyclodiphosphate 1 (ME-CPP) is synthesized from 1,2-O-isopropylidene-α-D-xylofuranose with facile phosphorylation in good yield. Subsequently, the synthesized enantiomerically pure 1 can be used as a substrate in IspG assays to identify inhibitors that may be developed into antibacterial drug leads.