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Communication | Special issue | Vol 76, No. 2, 2008, pp.1033-1042
Published online, 17th July, 2008
DOI: 10.3987/COM-08-S(N)88
Structure-Activity Relationship of Okadaic Acid, a Potent Protein Phosphatases PP1 and PP2A Inhibitor: 24-epi-Okadaic Acid and a 18-Membered Lactone Analog

Masaki Kita, Makoto Kuramoto, Tatsuhiko Chiba, Akihiro Yamada, Nobuko Yamada, Takako Ishida, Takeharu Haino, Kaoru Yamada, Yasuharu Ijuin, Osamu Ohno, and Daisuke Uemura*

*Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan


X-Ray crystallographic analysis and structure-activity relationship of okadaic acid revealed that the flexible cavity structure stabilized by intramolecular hydrogen bonds is important for its potent cytotoxicity.