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Communication | Regular issue | Vol 27, No. 1, 1988, pp.49-55
Published online, 1st January, 1970
DOI: 10.3987/COM-87-4346
2-(Heteroatom-substituted)methyl Penems. II. Sulphinyl and Sulphonyl Derivatives

Marco Alpegiani, Ettore Perrone, and Giovanni Franceschi

*Farmitalia Carlo Erba R&D, Via dei Gracchi 35, 20146 Milano, Italy

Abstract

Thermodynamic control of the endo-exo double bond equilibration in 2-(thiosubstituted) methyl penems allowed the synthesis of the sulphinyl and sulphonyl derivatives, which proved to be potent antibacter~al agents.