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Communication | Regular issue | Vol 27, No. 1, 1988, pp.71-74
Published online, 1st January, 1970
DOI: 10.3987/COM-87-4364
Facile Synthesis of Alcyclic Nucleosides Using a New Coupling Agent of Zinc Iodide

Yong Hae Kim* and Joong Young Kim

*Department of Chemistry, Korea Advanced Institute of Science and Technology, 373-1, Kusung-Dong, Yusung-Gu, Taejon, 305-701, Korea

Abstract

((1,3-Bis(benzyloxy)-2-propoxy)methyl)-2-thiopyrimidine-, uracil-, 2-thiouracil-, and 2-thioadenine- acyclic nucleosides and (2-acetoxyethoxy methyl)-2-thioadenine-, 2-thiopyrimidine-, uracil-, and 2 -thiouracil-acyclic nucleosides have been successfully synthesized in good yields by N-alkylation using a new Lewis acid, zinc iodide in dimethylformamide.