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Communication | Regular issue | Vol 27, No. 5, 1988, pp.1155-1158
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4508
Selective Synthesis of 1-Alkoxycarbonyloxymethyl-5-fluorouracils via 1,3-Bis(hydroxymethyl)-5-fluorouracil

Toshio Nagase,* Katsuto Shiraishi, Yutaka Yamada, and Shoichiro Ozaki*

*Faculty of Engineering, Ehime University, 3 Bunkyo-cho, Matsuyama, 790-8577 Ehime, Japan

Abstract

Esterification of 1,3-bis(hydroxymethyl)-5-fluorouracil with various alkyl chloroformates in the presence of tert- or hindered secalkylamine selectively gave potentially antitumor active 1-alkoxycarbonyloxymethyl-5-fluorouracils in moderate to good yields.