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Communication | Regular issue | Vol 27, No. 5, 1988, pp.1159-1162
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4510
t-Butyl Lithioacetate on ortho-Hydroxyphenones Providing 2-Methylchromones, an Easy Access to Khellin

Kazuo Nagasawa,* Hajime Kanbara, Kazuya Matsushita, and Keiichi Ito

*Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru 047-02, Japan

Abstract

Reaction of t-butyl lithioacetate with several kinds of poly-substituted ortho-hydroxyphenones including khellinone and subsequent acid-hydrolysis of the resulting hemiacetals provide the corresponding 2-methylchromone derivatives in excellent overall yields.