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Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Communication | Regular issue | Vol 27, No. 6, 1988, pp.1329-1340
Published online, 1st January, 1970■ 2-(Heteroaroma-substituted)methyl Penems. III. Nitrogen Derivatives
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4524
■ 2-(Heteroaroma-substituted)methyl Penems. III. Nitrogen Derivatives
Marco Alpegiani, Angelo Bedeschi, Ettore Perrone, Franco Zarini, and Giovanni Franceschi*
*Infectiond Diseases Dept., Farmitalia Carlo Erba R. & D., Via dei Gracchi 35, 20146 Milano, Italy
Abstract
The synthesis of “2-CH2 X” penems wherein X is N-imidoyl, N-heterocyclyl, amino or quaternary ammonium is described. The observed in vitro antibacterial activity marginally correlates with the electronic activation Induced by the X group on the β-lactam ring.
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