HETEROCYCLES

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■ 2-(Heteroaroma-substituted)methyl Penems. III. Nitrogen Derivatives

Marco Alpegiani, Angelo Bedeschi, Ettore Perrone, Franco Zarini, and Giovanni Franceschi*

*Infectiond Diseases Dept., Farmitalia Carlo Erba R. & D., Via dei Gracchi 35, 20146 Milano, Italy

Abstract

The synthesis of “2-CH₂ X” penems wherein X is N-imidoyl, N-heterocyclyl, amino or quaternary ammonium is described. The observed in vitro antibacterial activity marginally correlates with the electronic activation Induced by the X group on the β-lactam ring.