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Communication | Regular issue | Vol 27, No. 6, 1988, pp.1349-1351
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4542
Efficient Preparation of Penicillanate Ester: A Reductive Debromination of Bromopenicillanate Ester and Bromopenicillante-S,S-dioxide Easter with Tri-N-butylphosphine

Ji-Wang Chern,* Min Huang, Jung-Hsiung Tien, and Shou-Hsiung Pai

*Medical Laboratories and Institute of Pharmacy, National Defense Medical Center, P.O. Box 90048-512, Taipei, Taiwan, R.O.C.


Benzyl bromopenicillanate (5) and benzyl bromopenicillanate-S,S-dioxide (6) were subject to a reductive debromination in an effect of tri-n-butylphosphine furnishing benzyl penicillanate (7) and benzyl penicillanate-S,S-dioxide (8) in 50% and 81% yield respectively.