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Communication | Regular issue | Vol 27, No. 6, 1988, pp.1353-1356
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4544
Palladiun(0)-catalyzed Condensation of Bromopyridines with α-Substitutesd Acetonitriles

Takao Sakamoto, Eisaku Katoh, Yoshinori Kondo, and Hiroshi Yamanaka*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

The condensation of bromopyridines with the sodium salts of phenylsulfonylacetonitrile and diethyl cyanomethylphosphonate in the presence of tetrakis(triphenylphosphine) palladium in 1,2-dimethoxyethane gave the corresponding α-substituted pyridineacetonitrile derivatives in good yields.