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Paper | Regular issue | Vol 29, No. 1, 1989, pp.97-102
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4686
Synthesis of 4-Unsubstituted Isothiazoles

Francesco Lucchesini, Nevio Picci, Marco Pocci, Angela De Munno,* and Vincenzo Bertini

*Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Risorgnimento 35, I-56126 Pisa, Italy


A new method for the synthesis of 4-unsubstituted isothiazoles starting from α-acetylenic aldehydes or ketones, hydroxylamine-O-sulphonic acid and sodium hydrosulfide in buffered aqueous solution by one-pot procedure, is described.