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Communication | Special issue | Vol 28, No. 1, 1989, pp.163-166
Published online, 1st January, 1970
DOI: 10.3987/COM-88-S71
Synthesis of 1-Substituted Derivatives of Codeine from 1-Bromocodeine via Palladium Catalysed Coupling Reactions

Stephen G. Davies* and Dirk Pyatt

*Dyson Perrins Laboratory, Oxford University , South Parks Road, Oxford OX1 3QY, U.K.


The 1-(methyl-β-propenoate), 1-β-styryl, 1-carboethoxy and 1-methyl derivatives of codeine have been prepared in good yields from 1-bromocodeine via palladium catalysed coupling reactions.