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Paper | Regular issue | Vol 29, No. 9, 1989, pp.1689-1694
Published online, 1st January, 1970
DOI: 10.3987/COM-89-4957
Nortenuipine-2’β-N-oxide, a New Bisbenzylisoquinoline Alkaloid from Daphnandra dielsii

Ahmed M. Galal, Colin, D. Critchett, I. Ralph C. Bick, Subramaniam Sotheeswaran, Cong-yuan Gao, Fu-tyan Lin, Francis K. Duah, Emil W. Fu, Lan K. Wong, and Paul L. Schiff, Jr.*

*Department of Pharmaceutal Science, School of Pharmacy, University of Pittsburgh, University of Pittsburgh, U.S.A.


Repeated chromatography of the nonquaternary alkaloid fraction of an extract of the bark of Daphandra dielsii Perk. (Monimiaceae) over silica gel afforded the new bisbenzylisoquinoline alkaloid (-)-nortenuipine-2’β -N-oxide (1) which was characterized by a consideration of physicochemical data and reduction to (-)-nortenuipine. In addition, seven other bisbenzylisoquinoline alkaloids of known structure were isolated and identified.