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Paper | Regular issue | Vol 29, No. 7, 1989, pp.1391-1397
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5007
Enzymatic Cyclization of 2-(Carbamoyloxy)benzoates, 2-(Sulfamoyloxy)benzoates and 2-(Carbamoyloxy)benzophenones with Yeast and Lipase

Ahmed Kamal,* Maddamsetty V. Rao, Adari B. Rao, and Pralhad B. Sattur

*Division of Organic Chemistry, Regional Research Laboratory, Hyaderabad 500 007, India

Abstract

The cyclizatton of labile functionalized 2-(carbamoyloxy)-benzoates, 2-(sulfamoyloxy)benzoates and 2-(carbamoyloxy)benzophenones to 1,3-benzoxazine-2,4-diones, 4-oxo-3,4-dihydro-1,2,3-benzoxathiazine 2,2-dioxides and 4-phenyl-1,3-benzoxazin-2-ones with yeast as well as lipase is described. This approach establishes the application of enzymes for gram seale cyclization of such substrates under mild conditions. Further, it is revealed that baker’s yeast is most suitable for this process.