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Paper | Regular issue | Vol 29, No. 9, 1989, pp.1835-1842
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5076
The Practical Synthsis of N-Protected Allylamine: The Isoxazoline Route to Statine Analogue

Takahide Nishi* and Yasuhiro Morisawa

*Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan


The facile, practical synthesis of optically active N-protected allylamine from α-amino acid is described. The evolution of this work in the synthesis of statine analogue using [3+2] cycloaddition reaction is detailed.