Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 29, No. 9, 1989, pp.1849-1853
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5106
Enantiodivergent Synthesis of Both Enantiomers of Ibuprofen from (2S,3S)-3-Phenylglycidol

Seiichi Takano,* Masashi Yanase, and Kunio Ogasawara

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Enantiodivergent synthesis of both enantiomers of ibuprofen, a potent orally active anti-inflammatory agent, has been first established using (2S,3S)-3-phenylglycidol as a common starting material.