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Paper | Regular issue | Vol 31, No. 2, 1990, pp.367-372
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5253
Phosphorus Pentoxide in Organic Synthesis XXXX. Synthesis of 3-Aryl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-ones

Khalid Mohamed Hassan Hilmy, Jørgen Mogensen, Anker Jørgensen, and Erik B. Pedersen*

*Department of Chemistry, Odense University, Campusvej 55 DK-5230 Odense M., Denmark

Abstract

Pyrrolo[2,3-a]pyrimidin-4(3H)-ones (2a-j) were prepared in 18-51% yields by heating 2-acetylamino-3-pyrrolocarbonitriles (1) with a mixture of phosphorus pentoxide, N,N-dimethylcyclohexylamine hydrochloride, water, and n appropriate arylamine hydrochloride at 180 °C.