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■ Synthesis of Milrinone, a Cardiotonic Agent

Min-Jen Shiao,* Li-Ming Shyu, and Chieh-Fu Chen

*Institutue of Chemistry, Academia Sinica, 128, Yan-Chiu-Yuan Road, Sec II, Nankang, Taipei,11529, Taiwan, R.O.C.

Abstract

A new synthesis of milrione (6) from 6-methyl-5-(4-pyridiyl)-2(1H)-pyridone (4) is reported. A convenient synthesis of 3,4’-bipyridines (3a) and (3b) is achieved. 3a and 3b can be converted into pyridone 4 by hydrogenolysis and hydrolysis, respectively. Bromination at C-3 of the pyridone ring of 4 followed by cyanation affords milrinone (6).