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Paper | Regular issue | Vol 31, No. 3, 1990, pp.537-548
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5280
Synthesis of 2-Azolylcycloalkanols

Akira Murabayashi* and Yasuo Makisumi

*Aburahi Laboratories, Shionogi Research Laboratories, Koka-cho, Shiga 520-34, Japan


New 2-azolylcycloalkanol derivatives (13-38) were synthesized stereoselectively by Grignard reaction of 2-azolylcyclohexanones (7, 8), and particularly 2-azolylcycloheptanones (9, 10) afforded one of the diastereomers of 2-azolylcycloalkanols stereospecifically because the reagent attacked the carbonyl group from the less hindered side of the magnesium complex intermediate. These azolylcycloalkanols (13-38) were tested for antifungal activities.