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Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
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May 11, 2023
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Communication | Regular issue | Vol 31, No. 3, 1990, pp.411-414
Published online, 1st January, 1970■ An Enantiocontrolled Rotue to Unnatural (+)-Physostigmine
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5284
■ An Enantiocontrolled Rotue to Unnatural (+)-Physostigmine
Seiichi Takano,* Tsutomu Sato, Kohei Inomata, and Kunio Ogasawara
*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan
Abstract
ent-Esermetole (3), enantiomer of the key intermediate of physostigmine (1) and its other congeners, has been synthesized starting from the known optically active dihydronaphthalene (6) obtained via lipase mediated asymmetric hydrolysis.
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