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Communication | Regular issue | Vol 31, No. 3, 1990, pp.411-414
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5284
An Enantiocontrolled Rotue to Unnatural (+)-Physostigmine

Seiichi Takano,* Tsutomu Sato, Kohei Inomata, and Kunio Ogasawara

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


ent-Esermetole (3), enantiomer of the key intermediate of physostigmine (1) and its other congeners, has been synthesized starting from the known optically active dihydronaphthalene (6) obtained via lipase mediated asymmetric hydrolysis.