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Communication | Regular issue | Vol 31, No. 3, 1990, pp.419-422
Published online, 1st January, 1970
DOI: 10.3987/COM-89-5296
Base-induced Condensation of Phenols Joined by Amides to Ketones: A Synthesis of Hydroxylated Isoquinolinones and Derivatives

Richard Friary,* John H. Schwerdt, Vera Seidl, and John G. Topliss

*Schering-Plough Research, Schering-Plough Corporation, 86 Orange Street, Bloomfield, New Jersey 07003, U.S.A.


Pottassium carbonate in methanol saponified the acetate ester groups of certain meta-acetoxylated α-benzamido ketones and cyclized the resulting phenols in situ to give a series of hydroxylated isoquinolinones and derivatives.