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Paper | Special issue | Vol 30, No. 2, 1990, pp.855-862
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S62
Recent Work on the Synthesis of Phosphonate-containing, Bone-active Heterocycles

Frank H. Ebetino,* Charles R. Degenhardt, Laura A. Jamieson, and Don C. Burdsall

*Norwich Eaton Pharmaceuticals, Inc., Procter and Gamble Company, P. O. box 191, Norwich, New York 13815, U.S.A.

Abstract

New approaches to the design and synthesis of bone antiresorptive phosphonates have led to the discovery of the cyclic bisphosphonate series and the phosphonoalkylphosphinate heterocyclic series. The latter class, which offers substrates for interesting dianion chemistry, has ben shown to include effective bone-active isosteres of the well known bisphosphonates.