Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 30, No. 2, 1990, pp.855-862
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S62
Recent Work on the Synthesis of Phosphonate-containing, Bone-active Heterocycles

Frank H. Ebetino,* Charles R. Degenhardt, Laura A. Jamieson, and Don C. Burdsall

*Norwich Eaton Pharmaceuticals, Inc., Procter and Gamble Company, P. O. box 191, Norwich, New York 13815, U.S.A.


New approaches to the design and synthesis of bone antiresorptive phosphonates have led to the discovery of the cyclic bisphosphonate series and the phosphonoalkylphosphinate heterocyclic series. The latter class, which offers substrates for interesting dianion chemistry, has ben shown to include effective bone-active isosteres of the well known bisphosphonates.