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Paper | Special issue | Vol 30, No. 2, 1990, pp.875-884
Published online, 1st January, 1970
DOI: 10.3987/COM-89-S75
Syntheses of a Naturally Occurring Hydroxamic Acid and Its Analogues

Akihiro Ohta,* Nobuhiro Takahashi, Yasuko Shirokoma, Kayo Yuasa, Teruo Kurihara, and Hiroshi Miyamae

*Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


A naturally occurring cyclic hydroxamic acid, isolated from Pseudomonas species, and its analogues were synthesized via six steps starting from 2-hydroxy-3-methoxypyridine. The antimicrobial activity of the synthesized compounds is described.