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Paper | Regular issue | Vol 31, No. 3, 1990, pp.569-574
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5315
The Synthesis of 2’-Deoxy-5-trifluoromethyluridine Utilizing a Coupling Reaction

Hiroshi Kawakami,* Takashi Ebata, Koshi Koseki, Hajime Matsushita, Yoshitake Naoi, Kazuo Itoh, and Nobuhiro Mizutani

*Life Science Research Laboratory, Japan Tobacco Inc., 6-2, Umegaoka, Midori-ku, Yokohama, Kanagawa 227-8512, Japan


The coupling reaction between 1-α-chloro-2-deoxyribose derivatives and silylated 5-trifluoromethyluracil was examined. The best stereoselectively was obtained when the reaction was carried out using a large amount of silylated base in the presence of anhydrous zinc chloride.