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Communication | Regular issue | Vol 31, No. 7, 1990, pp.1195-1199
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5371
Synthesis of Benzoxolane Prostacyclin Analogue

Sachio Mori* and Shozo Takechi

*Shionogi Research Laboratories, Shionogi & Co. Ltd., Fukushima-ku, Osaka 553-0002, Japan

Abstract

Benzoxolane prostacyclin analogue ((±)-1) was synthesized with key step involving regio- and stereocontrolled carbon-carbon bond formation using allylic phosphate (17) and stabilized copper reagent derived from 15, followed by intramolecular selenoetherification leading to cylopentanobenzoxolane (19).