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Paper | Regular issue | Vol 31, No. 7, 1990, pp.1309-1314
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5407
Studies on Pyrazolo[3,4-d]pyrimidine Derivatives. XVIII. Facile Preparation of 1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-ones

Akira Miyashita,* Chihoko Iijima, Takao Higashino, and Hideaki Matsuda

*Schol of Pharmaceutical Sciences, University of Shizuoka, 395 Yada, Shizuoka 422, Japan

Abstract

Reaction of 5-amino-1-phenyl-1H-pyrazole-4-carboxamide (4) with the esters (3a-h) in the presence of sodium ethoxide in ethanol gave 1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (1a) and its 6-substitued derivatives (1b-h). Simlar treatment of 5-amino-1-methyl-1H-pyrazole-4-carboxamide (5) with 3a-h gave the 1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones (2a-h).