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Paper | Regular issue | Vol 31, No. 7, 1990, pp.1371-1375
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5430
Withangulatin A, a New Withanolide from Physalis angulata

Chiu-Ming Chen,* Zong-Tsi Chen, Chiu-Hsiang Hsieh, Wen-Sen Li, and Say-Yee Wen

*Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan 30013, Taiwan, R.O.C.


A new withanolide as a topoisomerase II inhibitor, withangulatin A was isolated from the whole herb of Physalis angulata L. (Solanaceae). The structure of withangulatin A was established as (20S,22R)-15α-acetoxy-5β,6β-epoxy-4β,14α-dihydroxy-1-oxowitha-2,16,24-trienolide (I) on the basis of spectroscopic and chemical evidence.