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Communication | Regular issue | Vol 31, No. 7, 1990, pp.1225-1228
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5435
An Enantioselective Synthesis of the Key Intermediate for the Preparation of 1β-Methylcarbapenem Antibiotics

Toshio Honda,* Hiroyuki Ishizone, Koichi Naito, and Yukio Suzuki

*Institute of Medical Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan


An enantioselective synthesis of the key intermediate for the preparation of 1β-methylcarbapenem has been achieved by employing the cyclopentane derivative (8), as a chiral source, readily derived from (-)-carvone.