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Communication | Regular issue | Vol 31, No. 9, 1990, pp.1565-1569
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5462
A Novel Route to 7-(Substituted Amino)-5,6-dihydrobenz[c]acridines

Lucjan Strekowski,* Roman L. Wydra, Donald B. Harden, and Vidya A. Honkan

*Department of Chemistry, Georgia State University, University Plaza, Atlanta, GA 30303, U.S.A.

Abstract

The title compounds (3) are produced in a novel, lithium alkylamide- and dialylamide-mediated cyclization of N-(1,2,3,4-tetrahydro-1-naphthylidene)-2-trifluoromethylaniline (2). The mechanism of this unusual transformation that involves the trifluoromethyl group is discussed.