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Communication | Regular issue | Vol 31, No. 9, 1990, pp.1571-1574
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5463
Synthesis of a Phosphonate Isostere of Acycylovir Monophosphate: A Herpesvirus Active Phosphonate Nucleotide Analogue

Choung Un Kim,* Peter F. Misco, Bing Y. Luh, and John C. Martin

*Bristol-Myers Squibb Company, Pharmaceutical Research and Development, 5 Research Parkway, Wallingford, CT 06492-5100, U.S.A.

Abstract

A novel synthetic methodology for the acyclic acetal functionality was developed. The rationally designed phosphonate analogue (3) of acyclovir monophosphate was active against herpesviruses.