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Paper | Regular issue | Vol 31, No. 9, 1990, pp.1635-1640
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5471
Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine: A New Heterocyclic Ring System

Fabrizio Bruni,* Stefano Chimichi,* Barbara Cosimelli, Annarella Costanzo, Gabriella Guerrini, and Silvia Selleri

*Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via Gino Capponi 9, I-50121 Firenze, Italy

Abstract

Treatment of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidine (1) with hydroxylamine afforded in high yields the pyridine N-oxide (2), a key intermediate in the preparation of new functionalized pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines as well as in the synthesis of the parent ring system (8).