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Paper | Regular issue | Vol 31, No. 9, 1990, pp.1647-1653
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5473
An Efficient Synthesis of 3-Alkyl-5-aryl-2(1H)-pyrazinones

Robert H. Bradbury,* David Griffiths, and Janet E. Rivett

*Department of Chemistry, ICI Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, U.K.

Abstract

The preparation of several 3-alkyl-5-aryl-2(1H)-pyrazinones is described. The regiochemical outcome of the condensation reaction between aminoacid amides and phenylglyoxal is discussed and an alternative, more efficient route is reported, involving ring-closure of α-oxo-N-(2-oxoethyl)carboxamides.