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Paper | Regular issue | Vol 31, No. 9, 1990, pp.1687-1691
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5492
Synthesis of β-Lactam Derivatives of 1,5-Benzoxazepines and 1,5-Benzothiazepines

Ines Torrini, Giampiero Pagani Zecchini, Mario Paglialunga Paradisi,* and Francesca Scazzocchio

*Dipartimento di Studi Farmaceutici, Facolta di Farmacia, Università degli Studi di Roma "La Sapienza", P.O.Box 36, P. le Aldo Moro 5, 00185 Roma, Italy

Abstract

Condensed β-lactam derivatives fo 1,5-benzoazepines (2a-i) and of 1,5-benzothiazepines (2j-r) have been synthesized by the reaction of quino[2,3-b][1,5]benzoxazepines (1a-c) or the corresponding benzothiazepines (1d-f) with some acyl chlorides in the presence of triethylamine. The formyl chloroacetamido derivatives (4a,b) were instead obtained by treating 1a,d with chloroacetyl chloride in the absence of the base. The mechanism of the reactions is discussed. No antibacterial activity was shown by the title compounds (2a-r) in the test experimental conditions.