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Paper | Regular issue | Vol 31, No. 11, 1990, pp.2073-2078
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5573
Asymmetric Synthesis of a Piperazine Alkaloid

Seiji Takeuchi,* Yoshiaki Ohgo, Norikazu Miyoshi, Chung-gi Shin, and Yasuchika Yonezawa

*Niigata College of Pharmacy, 5-13-2 Kamishin’ei-cho, Niigata 950-2081, Japan

Abstract

A piperazine alkaloid, (2S,5S)-2,5-dibenzyl-1,4-dimethylpiperazine, was synthesized by reduction of (3S,6S)-3,6-dibenzyl-1,4-diemthyl-2,5-piperazinedione which was prepared by a catalytic asymmetric hydrogenation of the corresponding 3,6-dibenzylidene derivative.