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Obituary
Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Communication | Regular issue | Vol 32, No. 1, 1991, pp.11-17
Published online, 1st January, 1970■ Gigantetrocin and Gigantriocin: Two Novel Bioactive Annonaceous Acetogenins from Goniothalamus giganteus
Published online, 1st January, 1970
DOI: 10.3987/COM-90-5610
■ Gigantetrocin and Gigantriocin: Two Novel Bioactive Annonaceous Acetogenins from Goniothalamus giganteus
Xin-Ping Fang, J. Kent Rupprecht, Ahmed Alkofahi, Yu-Hua Hui, Ya-Mei Liu, David L. Smith, Karl V. Wood, and Jerry L. McLaughlin*
*Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, 1333 Robert E. Heine Pharmacy Building, West Lafayette IN 47907, U.S.A.
Abstract
The structural elucidations of gigantetrocin, and gigantriocin two novel bioactive monotetrahydrofuran acetogenins with vicinyl hydroxyls are presented. These compounds are significantly and selectively cytotoxic to human tumor cells in culture and toxic to brine shrimp, and they inhibit the formation of crown gall tumors on potato discs, showing good potential for in vivo antitumor activities.
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