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■ Pyridazine Derivatives and Related Compounds Part 5. Pyrazolo[3,4-c]pyridazine: Synthesis and Some Reactions

Ali Deeb,* Besher Bayoumy, Abd El-Naby Essawy, and Rida Fikry

*Department of Chemistry, Faculty of Science, University of Zagazig, Zagazig, Egypt

Abstract

This paper describes the synthesis of three pyrimido[1’,2’: 1,5]pyrazolo[3,4-c]pyridazines (6, 7 and 9) starting from 3-amino[3,4-c]pyridazine (1). Pyrimido[5’,4’:5,6]pyrimido[1’,2’:1,5]pyrazolo[3,4-c]pyridazine derivatives (8) was obtained by condensing 7a with formamide. Reactions of 1 with acetic anhydride, benzoyl chloride, phenacyl bromide and 4-chlorophenacyl bromide gave 3-substituted amino derivatives.