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■ A Facile Synthesis of Substituted 4-Hydroxy-2-pyridones

Kun Hoe Chung, Kwang Yun Cho, Yasuko Asami, Nobutaka Takahashi,* and Shigeo Yoshida

*Department of Agricultural Chemistry, Faculty of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan

Abstract

Substituted 4-hydroxy-2-pyridones (1a-1d) were easily synthesized from ethyl acetoacetate in good yields via C-alkylation, enamine formation, N-acylation, intramolecular cyclization, and debenzylation.