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Communication | Regular issue | Vol 32, No. 3, 1991, pp.443-448
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5667
■ Simple Synthesis of 1,3,4,5-Tetrahydropyrrolo[4,3,2-de]quinoline and 5-Hydroxy-4-nitroindole (Synthetic Study for Indoles Having a Nitrogen Containing Functional Group at the 4-Position)

Shin Hamabuchi, Hirokazu Hamada, Akiko Hironaka, and Masanori Somei*

*Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

A simple four (or three) step synthesis method for 1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline (6) from indole-3-carboxaldehyde (9) is developed. A single step preparation of 5-hydroxy-4-nitroindole (8) by the oxidation of 4-aminoindole (16) is also reported.