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Communication | Regular issue | Vol 32, No. 5, 1991, pp.859-862
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5718
Synthesis of Dehydrodeoxypodophyllotoxin Cyclic Ether via Allene Intramolecular Cycloaddition Strategy and Evaluation of Its Cytotoxicity

Ken Kanematsu,* Michiko Tsuruoka, Yumiko Takaoka, and Takuma Sasaki

*Institute of Synthetic Organic Chemistry, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

Abstract

The new route to dehydrodeoxypodophyllotoxin cyclic ether (10) has been realized via allene intramolecular Diels-Alder reaction of the propargyl ether (8).