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Paper | Regular issue | Vol 32, No. 12, 1991, pp.2329-2338
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5787
Alternative Routes to Vincamine

András Nemes,* László Czibula, György Visky, Mária Farkas, and János Kreidl

*Chemical Works of Gedeon Richter Ltd., Budapest 10, P. O. Box 27, H-1475 Budapest, Hungary

Abstract

The preparation of vincamine (1a) via indoloquinolizine propionic esters (7) is discussed. A new synthesis of the starting material methyl 2-acetoxyacrylate and an oxidative transformation of 7b to 1a are described and an alternatvie, more efficient route is reported.