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Paper | Regular issue | Vol 32, No. 9, 1991, pp.1785-1792
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5800
Synthesis of Ring-enlarged Cyclobut-A and Cyclobut-G Analogues as HIV Inhibitors. Part 4

Hassane Boumchita, Michel Legraverend,* and Emile Bisagni

*URA 1387, CNRS, Institut Curie, Section de Biologie, Centre Universitaire, Bât., 110-112, 91405 Orsay, France

Abstract

Two ring-expanded analogues (compounds 13 and 14) of the anti-HIV agents Cyclobut-A and Cyclobut-G are described. They were synthesized from trans-3,4-bis(hydroxymethyl)cyclobutylamine which was obtained from threo-3,4-bis(methoxycarbonyl)hexane dioic acid. Neither compound (13, 14) was able to provide protection to CEM cells against HIV-1 infection.