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Paper | Regular issue | Vol 34, No. 1, 1992, pp.51-60
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5833
Polycondensed Heterocycles. VIII. Synthesis of 11-Aryl-5H,11H-pyrrolo[2,1-c][1,4]benzothiazepines by Pummerer Rearrangement-Cyclization Reaction

Antonio Garofalo, Giuseppe Campiani, Vito Nacci,* and Isabella Fiorini

*Dipartimento Farmaco Chimico Technologico, Università di Siena, Banchi di Sotto, 55 - 53100 Siena, Italy


11-Phenyl-5H,11H-pyrrolo[2,1-c][1,4]benzothiazepine has been prepared by an intramolecular nucleophilic displacement reaction. The same compound, as well as some analogues thereof, were more conveniently obtained by Pummerer rearrangement-cyclization of sulfinyl precursors. The latter method was also effective for the synthesis of 4-phenyl-4H-pyrrolo[2,1-c][1,4]benzothiazine.