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Communication | Regular issue | Vol 32, No. 11, 1991, pp.2093-2097
Published online, 1st January, 1970
DOI: 10.3987/COM-91-5859
Synthesis and DNA Binding Properties of a Purine Analogue of Bisbenzimide

Moses Lee,* P. Hunter Spotts, Jeffrey Eckert, Clint Walker, and Jennifer A. Nobles

*Department of Chemistry, Furman University, Greenville, South Carolina, U.S.A.

Abstract

The synthesis of a purine containing analogue (1) of bisbenzimide (2) and its DNA binding properties are described. Analogue 1 is found to have increased tolerance for binding to GC sites implying the formation of the new hydrogen bonds between guanine-2-NH2 in the minor groove of DNA and the concave purine N3 atom of 1.